diff --git a/.azure/ci-linux-job.yml b/.azure/ci-linux-job.yml
index 4260ca62..43926cda 100644
--- a/.azure/ci-linux-job.yml
+++ b/.azure/ci-linux-job.yml
@@ -44,7 +44,7 @@ jobs:
       $PYTHON --version 
       $MAKE_VENV
       source venv/bin/activate
-      python -m pip install -U pip setuptools wheel 
+      python -m pip install -U pip "setuptools<45" wheel 
       python -m pip install -r requirements.txt
     displayName: 'Install Python dependencies'
 
diff --git a/.azure/ci-macos-job.yml b/.azure/ci-macos-job.yml
index 91f4f8f4..b73fb757 100644
--- a/.azure/ci-macos-job.yml
+++ b/.azure/ci-macos-job.yml
@@ -40,7 +40,7 @@ jobs:
   - script: |
       curl -O https://bootstrap.pypa.io/get-pip.py
       $PYTHON get-pip.py
-      $PYTHON -m pip install -U setuptools wheel 
+      $PYTHON -m pip install -U "setuptools<45" wheel 
       $PYTHON -m pip install -r requirements.txt
     displayName: 'Install Python dependencies'
 
diff --git a/.azure/ci-windows-job.yml b/.azure/ci-windows-job.yml
index 72053dfd..d01cd6f4 100644
--- a/.azure/ci-windows-job.yml
+++ b/.azure/ci-windows-job.yml
@@ -53,7 +53,7 @@ jobs:
   - bash: |
       curl -O https://bootstrap.pypa.io/get-pip.py
       python get-pip.py
-      python -m pip install -U setuptools wheel 
+      python -m pip install -U "setuptools<45" wheel 
       python -m pip install -r requirements.txt
     displayName: 'Install Python dependencies'
 
diff --git a/requirements/devel.txt b/requirements/devel.txt
index 4a0577f3..73a9f9a7 100644
--- a/requirements/devel.txt
+++ b/requirements/devel.txt
@@ -1,7 +1,9 @@
 # Python packages needed for building and testing wxPython Phoenix
 -r install.txt
 appdirs
-setuptools
+setuptools < 45 ; python_version < '3.0'
+setuptools ; python_version >= '3.0'
+
 wheel
 twine
 requests